Aptamirror

Aptamirror is a meditative puzzle game in which you fold RNA strands to match target structures. You manipulate nucleotides with four tools—Grab, Mutate, Cleave and Ligate—and follow an illuminated ghost target as your fold approaches the solution. The game has 50 levels across 10 chapters, from your first hairpin to multi-strand puzzles, culminating in a prismatic endgame.

Learn the tools

Early puzzles introduce each mechanic on its own. Later challenges call for fluent use of all four tools, including deciding when to cut a strand, mutate a base or join two halves.

Solve at your own pace

Puzzles wait for you, and you can experiment freely or reset at any time. There is no pressure beyond the goals you set yourself, such as finding a cleaner solution, using fewer moves or earning a perfect three-star fold. Stars unlock backbone and cursor colors, and mastering every level leads to the prismatic endgame.

RNA and the puzzles

A PhD biochemist designed Aptamirror, and its puzzles are rooted in real science. You do not need prior knowledge of RNA to play.