Against the Gradient
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About Against the Gradient
Against the Gradient is a puzzle game about cellular transport. You place transporters in cell membranes to move molecules and ions into or out of cells, aiming to reach specific concentrations.
Cellular transport puzzles
More than 20 puzzles introduce the principles of cellular transport, from gentle introductions to challenging puzzles. You use channels, co-transporters and antiporters to work with facilitated diffusion and active transport. The mechanics are based on real biological principles, and you can speed up or slow down time to play at your own pace.
Transporters and level editor
The game includes 16 transporters, including real proteins found in the human body and imaginative nano-robots. A built-in level editor lets you create your own puzzles to challenge your friends.
Frequently asked questions
The best price for Against the Gradient is $2.99 at Steam. It is the only shop with an offer that activates in your country.
The minimum requirements for Against the Gradient are: Windows XP, 1 GB RAM, 100 MB storage. It also runs on macOS. The recommended specs are in the System requirements section.
No. Against the Gradient is a single-player game.
Yes. Against the Gradient is the full base game. You need nothing else to play it.
Steam lets publishers create keys to sell in other shops. Once you activate a key, the game is yours to keep, just like a store purchase.
Disclaimer: CD keys have an inherent 1–2% average failure rate. Check the shop terms for buyer protection info. Steam offers no buyer protection for keys bought in other shops and doesn't refund them.











